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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
17.27
Human Site:
S1469
Identified Species:
27.14
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1469
N
R
R
K
R
K
P
S
T
S
D
D
S
D
S
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
K1516
S
D
T
V
P
K
P
K
R
A
P
K
Q
K
K
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
K1502
S
D
T
A
P
K
P
K
R
A
P
K
Q
K
K
Dog
Lupus familis
XP_537646
1532
174610
S1470
N
H
R
K
R
K
P
S
T
S
D
D
S
D
S
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S1465
N
S
R
K
R
K
P
S
S
S
D
S
S
D
S
Rat
Rattus norvegicus
P41516
1526
173202
S1465
N
S
R
K
R
M
P
S
S
S
D
S
S
D
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
G1499
S
P
G
I
S
G
S
G
P
E
S
S
P
G
W
Chicken
Gallus gallus
O42130
1553
174974
S1491
R
L
T
S
S
S
D
S
D
S
D
F
G
S
R
Frog
Xenopus laevis
NP_001082502
1579
178601
A1484
A
T
K
S
K
A
A
A
K
K
P
S
S
D
S
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
S1478
T
A
V
K
P
L
S
S
D
S
D
S
A
G
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
S1385
E
D
G
G
N
V
G
S
D
D
D
G
N
A
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
T1454
E
P
K
S
K
A
V
T
D
F
F
G
A
S
K
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
S1386
E
H
L
D
D
V
T
S
G
D
A
A
L
A
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
V1403
F
N
K
K
S
S
S
V
M
S
R
L
A
D
N
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
R1367
I
L
D
S
Y
T
D
R
E
D
S
N
K
D
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
13.3
13.3
93.3
N.A.
80
73.3
N.A.
0
20
20
26.6
N.A.
20
N.A.
0
6.6
P-Site Similarity:
100
26.6
26.6
93.3
N.A.
86.6
80
N.A.
6.6
20
40
33.3
N.A.
26.6
N.A.
26.6
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
7
0
14
7
7
0
14
7
7
20
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
20
7
7
7
0
14
0
27
20
47
14
0
47
0
% D
% Glu:
20
0
0
0
0
0
0
0
7
7
0
0
0
0
7
% E
% Phe:
7
0
0
0
0
0
0
0
0
7
7
7
0
0
0
% F
% Gly:
0
0
14
7
0
7
7
7
7
0
0
14
7
14
0
% G
% His:
0
14
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
20
40
14
34
0
14
7
7
0
14
7
14
20
% K
% Leu:
0
14
7
0
0
7
0
0
0
0
0
7
7
0
0
% L
% Met:
0
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% M
% Asn:
27
7
0
0
7
0
0
0
0
0
0
7
7
0
7
% N
% Pro:
0
14
0
0
20
0
40
0
7
0
20
0
7
0
7
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
14
0
0
% Q
% Arg:
7
7
27
0
27
0
0
7
14
0
7
0
0
0
7
% R
% Ser:
20
14
0
27
20
14
20
54
14
47
14
34
34
14
40
% S
% Thr:
7
7
20
0
0
7
7
7
14
0
0
0
0
0
0
% T
% Val:
0
0
7
7
0
14
7
7
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _